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ABSTRACT OBJECTIVE：To establish a method for content determination of paclitaxel in malignant ascites of tumor patients. METHODS：LC-MS/MS method was adopted. Using vindoline as internal standard，the content of paclitaxel in ascites of tumor patients was determined. The separation was performed on Zorbax SB-C18 column with mobile phase consisted of aqueous solution （containing 0.1％ formic acid and 10 mmol/L ammonium acetate）-acetonitrile（40 ∶ 60，V/V）at the flow rate of 0.25 mL/min. the column temperature was 30 ℃，and sample size was 5 μL. The ion source was electrospray ion source，and the detection mode was multiple ion monitoring positive ion mode. MS parameters were set as following as dry gas temperature 350 ℃，dry gas flow rate 10 L/min，capillary voltage 4 000 V. Quantitative determination was operated in the multiple reaction monitoring（MRM）mode， with the ion transitions m/z 876.5→308.0 for paclitaxel and m/z 457.3→188.1 for the internal standard. The fragment voltage/ collision energy for paclitaxel and the internal standard were 250 V/30 eV，and 150 V/20 eV，respectively. RESULTS：The linear range of paclitaxel were 25-2 500 ng/mL（r2＝0.996 5，n＝7）. The lowest limit of quantitation was 25 ng/mL. RSDs of inter-day and intra-day precision tests were 0.61％ -3.62％（n＝5，3）. Accuracies were 95.34％ -98.76％（n＝5，3）. RSDs of extraction recovery were 3.19％-3.72％（n＝3）. CV of matrix effect were 1.52％-2.93％（n＝3）. RE of stability tests were lower than 3％（n＝ 3）. CONCLUSIONS：The method is simple，accurate and suitable for the content determination of paclitaxel in malignant ascites of tumor patients.
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Objective: To explore the incidence and risk factors of infection related to totally implantable access port (TIAP) in upper arm in cancer patients. Methods: A total of 1 961 patients who received TIAP for deliverance of chemotherapy at Renji Hospital, Shanghai Jiao Tong University School of Medicine during the period from February 2014 to December 2018. The general clinical data, catheterization status, bacteriological data and incidence of TIAP-related infections were retrospectively analyzed. The univariate analysis and multivariate Logistic regression analysis were used to determine the risk factors TIAP-related infections. Results: A total of 43 patients developed TIAP-related infections, with an incidence of 2.2% (43/1 961). The mean time interval from the implantation of upper arm TIAP to the diagnosis of infection was (116.88±95.39) d (7-377 d). In univariate analysis, gender (P=0.001), catheter diameter (P=0.000), upper extremity venous thrombosis (UEVT) (P=0.000) and outpatient (P=0.005) were significantly associated with the risk of infection related to upper arm TIAP. Multivariate binary Logistic regression analysis showed that gender (OR=0.35, P=0.012), UEVT (OR=31.59, P=0.000) and catheter diameter (OR=2.81, P=0.005) were three significant independent predictors of infection related to upper arm TIAP. Conclusion: Gender, UEVT and catheter diameter are independent risk factors for upper arm TIAP-related infection.
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Objective To investigate the incidence of venous thrombosis related to totally implantable access port (TIAP) in upper arm in cancer patients, and to discuss its risk factors. Methods The clinical data of a total of 1 724 patients, who received upper arm TIAP for deliverance of chemotherapy at authors' hospital during the period from February 2014 to April 2018, were collected. The general data of patients, catheterization, disease progression and incidence of venous thrombosis in upper limbs were analyzed. The univariate analysis and multivariate logistic regression analysis were used to determine the risk factors related to symptomatic thrombus. Results A total of 17 patients developed symptomatic venous thrombosis of the upper extremities, the incidence rate was 0.99％ (17/1 724) . The mean time interval from the implantation of upper arm TIAP to the diagnosis of thrombosis was 55.6 d (2-334 d) . Univariate analysis indicated that infection (P<0.01) and spontaneous catheter dislodgment (P<0.01) were significantly related to the risk of upper extremity venous thrombus (UEVT) . Multivariate binary logistic regression analysis revealed that infection (RR =16.85, P <0.01) and catheter spontaneous dislodgment (RR =101.09, P <0.01) were two important independent predictors for UVTE related to upper arm TIAP. Conclusion Infection and spontaneous catheter dislodgment are independent risk factors for upper arm TIAP-related thrombosis.
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At present, most of the malignancies still have poor treatment and even poor prognosis .In the case of disease informing , the families of many patients with malignant tumors are inclined to conceal the disease based on the risks that may result in the patient ' s pain while patients want to know their disease diagnosis and prognosis . Telling patients the truth is helpful to promote the patients to participate in the treatment decision , cooperate with the treatment, prolong the survival time , improve the quality of life and also is the requirement of relevant laws and regulations, but it also faces many ethical conflicts in practice .Aiming at this, this paper proposed to strengthen health education , make necessary training to medical staff , design individual informative programs , cooperate rea-sonably with family members , and so on .
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At present, most of the malignancies still have poor treatment and even poor prognosis .In the case of disease informing , the families of many patients with malignant tumors are inclined to conceal the disease based on the risks that may result in the patient ' s pain while patients want to know their disease diagnosis and prognosis . Telling patients the truth is helpful to promote the patients to participate in the treatment decision , cooperate with the treatment, prolong the survival time , improve the quality of life and also is the requirement of relevant laws and regulations, but it also faces many ethical conflicts in practice .Aiming at this, this paper proposed to strengthen health education , make necessary training to medical staff , design individual informative programs , cooperate rea-sonably with family members , and so on .
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Objective To investigate the prevalence of healthcare-associated infection(HAI)in a tumor hospital,and provide evidence for prevention and control of HAI.Methods According to requirement of cross sectional survey of nationwide HAI monitoring network,prevalence rates of HAI in hospitalized patients at a tumor hospital in 2013-2015 were surveyed,surveyed results were statistically analyzed.Results A total of 3 515 hospitalized patients were investigated from 2013 to 2015,24(0.68%)had HAI.The prevalence rates of HAI from 2013 to 2015 were 0.79%,0.54%,and 0.76%respectively,difference was not statistically significant(x2=0.65,P>0.05).The main infection site was lower respiratory tract,accounting for 45.83%.The main pathogens causing HAI were gram-negative bacilli,accounting for 47.37%,followed by fungi(26.32%).Conclusion The prevalence rate of HAI in tumor patients is low,targeted monitoring should be carried out according to the current situation,the prevention and control of lower respiratory tract infection should be focused on,fungal infection should be paid attention.
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Objective To study the difference on knowledge-attitude-practice about rational drug use in tumor patients between urban and rural in Shanxi province, and to provide evidence for further development on health education of rational drug use. Methods A questionnaire investigation was conducted among tumor inpatients in Shanxi Cancer Hospital from May 22 in 2014 to May 30 in 2014. Results A total of 990 tumor patients were involved, including 499 urban patients accounting for 50.4 % and 491 rural patients accounting for 49.6 %. The tumor patients′awareness rates of 'the purchase of antibiotics needs a prescription' in urban and rural areas were the highest, 74.9 % (374/499) and 67.0 % (329/491), respectively, and the awareness rates of 'the meaning of OTC on the medicine package' were the lowest, 22.0 % (110/499) and 18.1 % (89/491), respectively. 96.2%(480/499) urban and 92.7%(455/491) rural tumor patients had developed a correct attitude towards 'irrational drug use will affect health and even life-threatening' which ranked the highest, and the rates of correct attitude towards 'adverse drug reaction is the medical accident' were the lowest, 55.5 %(277/499) and 48.1 % (236/491), respectively. The correct behavior rates of 'read the drug instructions' in urban and rural tumor patients were the highest, 97.8% (488/499) and 95.1 % (467/491), respectively, and the correct behavior rates of 'the expired drug recovery to nearby regular pharmacy' were the lowest, 9.2 %(46/499) and 7.5 % (37/491), respectively. Conclusions The knowledge-attitude-practice about rational drug among urban and rural tumor patients in Shanxi province is not optimistic. It should be provided that individual health education in daily work in order to promote rational drug use, prolong survival time and improve the quality of life for tumor patients.
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OBJECTIVE: The aim of this study was to evaluate the reliability and validity of the Pediatric Functional Assessment of Cancer Therapy Questionnaire Brain Tumor Survivor (version 2.0) Aged 13 years and older (Parent Form) (pedsFACT-BrS parent of adolescent). METHODS: The pedsFACT-BrS parent of adolescent was translated and cross-culturally adapted into Korean, following standard Functional Assessment of Chronic Illness Therapy (FACIT) methodology. The psychometric properties of the pedsFACT-BrS parent of adolescent were evaluated in 170 brain tumor patient's mothers (mean age=43.38 years). Pretesting was performed in 30 mothers, and the results indicated good symptom coverage and overall comprehensibility. The participants also completed the Child Health Questionnaire Parent Form 50 (CHQ-PF-50), Neuroticism in Eysenck Personality Questionnaire, and Karnofsky score. RESULTS: In validating the pedsFACT-BrS parent of adolescent, we found high internal consistency, with Cronbach's alpha coefficients ranging from 0.76 to 0.94. The assessment of test-retest reliability using intraclass correlation coefficient revealed satisfactory values with ICCs ranging from 0.84 to 0.93. The pedsFACT-BrS for parent of adolescent also demonstrated good convergent and divergent validities when correlated with the Child Health Questionnaire Parent Form 50 (CHQ-PF-50) and the Neuroticism in Eysenck Personality Questionnaire. The pedsFACT-BrS parent of adolescent showed good clinical validity, and effectively differentiated between clinically distinct patient groups according to the type of treatment, tumor location, shunt, and Karnofsky score of parent proxy report. CONCLUSION: We confirmed that this reliable and valid instrument can be used to properly evaluate the quality of life of Korean adolescent brain tumor patients by their parents' proxy report.
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Adolescent , Aged , Child , Humans , Anxiety Disorders , Brain , Brain Neoplasms , Child Health , Chronic Disease , Mothers , Parents , Proxy , Psychometrics , Quality of Life , Surveys and Questionnaires , Reproducibility of Results , SurvivorsABSTRACT
OBJECTIVE To investigate the HIV infections states in tumor patients for clinical diagnosis,treatment and to prevent HIV infection in the tumor hospital.METHODS The result of HIV detection in tumor patients from Dec 2000 to Aug 2006 was analyzed by the review statistics analysis.RESULTS Totally 48 101 tumor paients were detected,and the number of tumor patients with positive HIV antibody result was 51(0.106%).Among the positive patients there were 21 cases with blood transfusion history,14 cases with blood donating experience,2 cases with both these two kinds of experiences and 14 cases without the two kinds of experiences.Their rate was separately 41.0%,27.5%,4.0% and 27.5%.Most of the HIV positive patients had no clinical synptoms.CONCLUSIONS The HIV positive rate of patients with blood transfusion or blood donating is significantly higher than the patients without these experiences.The routine detection for the HIV before the operation,blood transfusion or other traumatic detection is very necessary.